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Efficacy Safety & Tolerability
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Information for Physicians

Treat Acne Firmly

ACZONE® was studied in a broad range of patients with demonstrated success. It treats acne with efficacy.

Studied in a Broad Range of Patients

Pivotal study included over 3,000 participants of various ethnicities, drawn from 103 centers in all climates, including harsh winter zones1.

Demonstrated Success

Efficacy Comes First

Global Acne Assessment Score (GAAS) of 41% success (little or no acne) after 12 weeks in participants treated with ACZONE® (dapsone) Gel 5% vs. 33% for vehicle1.

Efficacy by Gender

Women tended to have better results

After 12 weeks of clinical trials, responses to ACZONE® Gel were higher in both GAAS success and lesion reduction measures.2,3

Minimal Withdrawals

Patients withdrawn from the study due to lack of efficacy were 9 out of more than 1,500 participants.1

Before and After Photos

Before
Week 12
ACZONE® Acne Results Sample 1 Before ACZONE® Acne Results Sample 1 After
ACZONE® Acne Results Sample 2 Before ACZONE® Acne Results Sample 2 After
ACZONE® Acne Results Sample 3 Before ACZONE® Acne Results Sample 3 After
ACZONE® Acne Results Sample 4 Before ACZONE® Acne Results Sample 4 After
ACZONE® Acne Results Sample 5 Before ACZONE® Acne Results Sample 5 After
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Aczone

ACZONE® (dapsone) Gel 5% is approved for the topical treatment of acne vulgaris.

IMPORTANT SAFETY INFORMATION

Do not use ACZONE® Gel if you are allergic to any of the ingredients in ACZONE® Gel or if you are younger than 12 years of age.

Tell your doctor about all of your medical conditions, including if you have glucose-6-phosphate dehydrogenase deficiency.

Like all medicines, ACZONE® Gel can cause some side effects. The most common side effects of ACZONE® Gel are dryness, redness, oiliness, and peeling of the skin being treated.

When the active ingredient of ACZONE® Gel (called dapsone) is taken orally as a pill, it has been related to the abnormal breakdown of red blood cells (hemolytic anemia). If you have glucose-6-phosphate dehydrogenase deficiency, you may have a greater risk for lowering your hemoglobin level. However, using ACZONE® Gel on the skin is not expected to put enough dapsone in the blood to cause clinical symptoms of hemolytic anemia. You are advised to be alert for signs and symptoms suggestive of this type of anemia (sudden onset of: back pain, breathlessness, tiredness/weakness with daily activities, dark-brown urine, high fever, and yellow or pale skin). If you experience these signs and symptoms, stop use and call your doctor immediately.

Use of benzoyl peroxide together with ACZONE® Gel at the same time may cause your skin to temporarily turn yellow or orange at the site of application.

Click Here for Full Prescribing Information

  1. Draelos ZD, Carter E, Maloney JM, et al; for United States/Canada Dapsone Gel Study Group. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007;56(3):439.e1-439.e10.
  2. ACZONE® Prescribing Information. Irvine, CA: Allergan, Inc; 2008.
  3. Data on file, Allergan, Inc., February 8, 2010; Brunet JS, Marier JF, Meta-analysis to assess the impact of sub populations on the efficacy of ACZONE®. Protocols DAP0203 and DAP 0204.