Results for vehicle: 2 weeks 22%, 4 weeks 31%, 6 weeks 35%, 8 weeks 38%,12 weeks 42%.

• 3010 study subjects¹
• 24% reduction as early as week 2¹
• 35% reduction at week 4¹
• 48% reduction at week 12¹

Results for vehicle: 42% reduction in inflammatory acne at the end of 12 weeks

Total lesion count also reduced¹

Results for vehicle: 2 weeks 14%, 4 weeks 21%, 6 weeks 25%, 8 weeks 28%,12 weeks 32%

Learn more about safety and tolerability >

ACZONE^® (dapsone) Gel 5% is indicated for the topical treatment of acne vulgaris.

Important Safety Information

WARNINGS AND PRECAUTIONS

Hematological effects: Oral dapsone treatment has produced dose-related hemolysis and hemolytic anemia. Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more prone to hemolysis with the use of certain drugs. There was no evidence of clinically relevant hemolysis or anemia in patients treated with ACZONE^® Gel 5%, including patients who were G6PD deficient. Some subjects with G6PD deficiency using ACZONE^® Gel developed laboratory changes suggestive of mild hemolysis.

If signs and symptoms suggestive of hemolytic anemia occur, ACZONE^® Gel 5% should be discontinued. ACZONE^® Gel 5% should not be used in patients who are taking oral dapsone or antimalarial medications because of the potential for hemolytic reactions. Combination of ACZONE^® Gel 5% with trimethoprim/sulfamethoxazole (TMP/SMX) may increase the likelihood of hemolysis in patients with G6PD deficiency.

Peripheral neuropathy: Peripheral neuropathy (motor loss and muscle weakness) has been reported with oral dapsone treatment. No events of peripheral neuropathy were observed in clinical trials with topical ACZONE^® Gel 5% treatment.

Skin: Skin reactions (toxic epidermal necrolysis, erythema multiforme, morbilliform and scarlatiniform reactions, bullous and exfoliative dermatitis, erythema nodosum, and urticaria) have been reported with oral dapsone treatment. These types of skin reactions were not observed in clinical trials with topical ACZONE^® Gel 5% treatment.

ADVERSE REACTIONS:

The most common adverse reactions of ACZONE^® Gel 5% (incidence ≥ 10%) are oiliness/peeling, dryness, and erythema at the application site.

Free TrialContact AllerganPrivacy PolicySite Map